You have performed several experiments measuring potential biomarkers in blood serum of glioma patients and have acquired the following data. The levels are mean levels of 110 high grade glioma, 55 low grade glioma and 33 non-cancerous patient serum samples. The standard error of the patient cohort is also given. Biomarker HGG Mean level (pg/ml) Standard error LGG Mean level (pg/ml) Standard error Non cancerous Mean level (pg/ml) Standard error Follistatin 2009.6 71.3 1954.8 93.7 1548.4 78.4 PDGF 8536.8 355.5 8572.4 391.9 7315.1 603.9 G-CSF 435.4 16.2 413.1 13.2 379.3 9.4 Prolactin 32603.8 3541.9 28875.7 3667.8 8101.9 802.9 PECAM-1 4907.3 147.4 4918.0 215.0 5382.4 236.7 sHER2 neu 3615.8 13.4 4079.5 227.2 4845.3 252.0 Leptin 8919.5 715.8 10420.7 1284.5 15315.8 2362.3 Show which potential biomarkers could be used to differentiate patients with high grade and/or low grade glioma from each other and from non-cancerous patients? (10 marks). How would you calculate the statistical power of the results between HGG vs LGG HGG vs Non-cancerous LGG vs Non-cancerous (10 marks)
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